Chemical detection and analysis of Astragalus-Cassia twig drug pair using UHPLC-Q-TOF-MS and HPLC-UV methods.
Fitoterapia
; 177: 106129, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39047846
ABSTRACT
The classic Astragalus-Cassia twig drug pair has a long history of proven efficacy. However, a fewer studies on material basis of the Astragalus and Cassia twig decoction (ACD) was researched at present. The method of UPLC-Q-TOF-MS for classifying and identifying the main chemical components of ACD was established and the differences in composition between single decoction and co-decoction were compared by using HPLC-UV. The therapeutic role of ACD on type 2 diabetes (T2D) rats was investigated. Thirty-five compounds were resolved from the ACD. Fifteen compounds were deduced from the decoction of Astragalus, whereas nine compounds were identified from Cassia twig. Pairing of herbs make a significant effect on the chemical composition of herbal decoction. ACD can play a more obvious role in alleviating the symptoms of T2D rats, compared to the application of single herb.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Astragalus Plant
Limits:
Animals
Language:
En
Journal:
Fitoterapia
Year:
2024
Document type:
Article
Affiliation country: