Effect of chlorpyrifos on cypermethrin-induced dopaminergic neurotoxicity in rats.
Toxicol Ind Health
; : 7482337241267192, 2024 Jul 29.
Article
in En
| MEDLINE
| ID: mdl-39075981
ABSTRACT
The study aimed to investigate the combined effects of chlorpyrifos and cypermethrin combined on dopaminergic neurotoxicity, motor behaviours and level of selected inflammatory proteins in rats compared to either alone for delineating an interaction between these two pesticides. The rotarod and grip strength tests were employed to assess neurobehavioural changes. The striatal dopamine content and expression of tyrosine hydroxylase (TH), α-synuclein, cyclooxygenase-2 (COX-2), and tumour necrosis factor-α (TNF-α) proteins in the nigrostriatal tissue were measured. Chlorpyrifos impaired the neurobehavioural indexes, reduced the striatal dopamine level, augmented the level of α-synuclein, COX-2, and TNF-α and attenuated the expression of TH similar to but a little less than cypermethrin. Half the dose of both pesticides together produced additional neurotoxicity compared with the usual (highest employed) dose of either alone. The results showed that chlorpyrifos induced moderately less dopaminergic neurotoxicity than cypermethrin. In the combination, they produced a little higher toxicity than either pesticide alone.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Toxicol Ind Health
Journal subject:
MEDICINA OCUPACIONAL
/
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country: