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Visual and auditory attention in individuals with DYRK1A and SCN2A disruptive variants.
Hudac, Caitlin M; Dommer, Kelsey; Mahony, Monique; DesChamps, Trent D; Cairney, Brianna; Earl, Rachel; Kurtz-Nelson, Evangeline C; Bradshaw, Jessica; Bernier, Raphael A; Eichler, Evan E; Neuhaus, Emily; Webb, Sara Jane; Shic, Frederick.
Affiliation
  • Hudac CM; Department of Psychology, University of South Carolina, Columbia, South Carolina, USA.
  • Dommer K; Center for Autism and Neurodevelopment (CAN) Research Center, University of South Carolina, Columbia, South Carolina, USA.
  • Mahony M; Institute for Mind and Brain, University of South Carolina, Columbia, South Carolina, USA.
  • DesChamps TD; Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Cairney B; Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.
  • Earl R; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
  • Kurtz-Nelson EC; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
  • Bradshaw J; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
  • Bernier RA; Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
  • Eichler EE; Department of Psychology, University of South Carolina, Columbia, South Carolina, USA.
  • Neuhaus E; Center for Autism and Neurodevelopment (CAN) Research Center, University of South Carolina, Columbia, South Carolina, USA.
  • Webb SJ; Institute for Mind and Brain, University of South Carolina, Columbia, South Carolina, USA.
  • Shic F; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA.
Autism Res ; 2024 Jul 30.
Article in En | MEDLINE | ID: mdl-39080977
ABSTRACT
This preliminary study sought to assess biomarkers of attention using electroencephalography (EEG) and eye tracking in two ultra-rare monogenic populations associated with autism spectrum disorder (ASD). Relative to idiopathic ASD (n = 12) and neurotypical comparison (n = 49) groups, divergent attention profiles were observed for the monogenic groups, such that individuals with DYRK1A (n = 9) exhibited diminished auditory attention condition differences during an oddball EEG paradigm whereas individuals with SCN2A (n = 5) exhibited diminished visual attention condition differences noted by eye gaze tracking when viewing social interactions. Findings provide initial support for alignment of auditory and visual attention markers in idiopathic ASD and neurotypical development but not monogenic groups. These results support ongoing efforts to develop translational ASD biomarkers within the attention domain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Autism Res Journal subject: PSIQUIATRIA / TRANSTORNOS MENTAIS Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Autism Res Journal subject: PSIQUIATRIA / TRANSTORNOS MENTAIS Year: 2024 Document type: Article Affiliation country: Country of publication: