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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
Leyte-Vidal, Ariel; DeFilippis, RosaAnna; Outhwaite, Ian R; Kwan, Isabelle; Lee, Ji Young; Leavitt, Carlyn; Miller, Kaeli B; Rea, Delphine; Rangwala, Aziz M; Lou, Kevin; Patel, Suhana; Alvarez, Ailin; Shokat, Kevan M; Bahar, Ivet; Seeliger, Markus A; Shah, Neil P.
Affiliation
  • Leyte-Vidal A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • DeFilippis R; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.
  • Outhwaite IR; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • Kwan I; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Lee JY; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Leavitt C; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Miller KB; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Rea D; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Rangwala AM; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • Lou K; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • Patel S; Adult Hematology Department, Hôpital Saint-Louis, Paris, France.
  • Alvarez A; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.
  • Bahar I; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.
  • Seeliger MA; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
  • Shah NP; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
Leukemia ; 38(9): 2046-2050, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39085402
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exons / Fusion Proteins, bcr-abl / Drug Resistance, Neoplasm Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exons / Fusion Proteins, bcr-abl / Drug Resistance, Neoplasm Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication: