Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging.
EJNMMI Radiopharm Chem
; 9(1): 57, 2024 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-39093479
ABSTRACT
BACKGROUND:
The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of 52Mn for PET/MRI imaging.RESULTS:
Using the 52Cr(p,n)52Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating 52Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality 52Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.CONCLUSIONS:
The developed technology offers a promising avenue for producing 52Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
EJNMMI Radiopharm Chem
Year:
2024
Document type:
Article
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