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Single gene mutations and prognosis in limited-stage follicular lymphoma treated with radiation therapy.
Hershenfeld, Samantha A; Tobin, Josuha W D; Shelton, Victoria; Calvente, Lourdes; Lajkosz, Katherine; Liu, Ting; Brodtkorb, Marianne; d'Amore, Francesco Annibale; Ludvigsen, Maja; Baetz, Tara; LeBrun, David; Johnson, Nathalie; Crump, Michael; Hong, Michael; Kuruvilla, John; Tremblay-LeMay, Rosemarie; MacManus, Michael; Tsang, Richard; Hodgson, David C; Gandhi, Maher K; Kridel, Robert.
Affiliation
  • Hershenfeld SA; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Tobin JWD; Mater Research University of Queensland, Brisbane, Queensland, Australia.
  • Shelton V; Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
  • Calvente L; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Lajkosz K; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Liu T; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Brodtkorb M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • d'Amore FA; Department of Oncology, Oslo University Hospital, Oslo, Norway.
  • Ludvigsen M; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Baetz T; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • LeBrun D; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Johnson N; Queen's University, Kingston, Ontario, Canada.
  • Crump M; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
  • Hong M; Departments of Medicine and Oncology, Jewish General Hospital, Montreal, Quebec, Canada.
  • Kuruvilla J; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Tremblay-LeMay R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • MacManus M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Tsang R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Hodgson DC; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Gandhi MK; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
  • Kridel R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
Br J Haematol ; 2024 Aug 07.
Article in En | MEDLINE | ID: mdl-39112220
ABSTRACT
Radiotherapy is routinely used for management of limited-stage follicular lymphoma (FL), yet half of patients ultimately relapse. We hypothesized that the presence of specific gene mutations may predict outcomes. We performed targeted sequencing of a 69-gene panel in 117 limited-stage FL patients treated with radiotherapy and identified recurrently mutated genes. CREBBP was most frequently mutated, and mutated CREBBP was associated with inferior progression-free survival, though not after false discovery rate adjustment. This association failed to validate in an independent cohort. We conclude that recurrent gene mutations do not predict outcomes in this setting. Alternative biomarkers may offer better prognostic insight.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Br J Haematol Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Br J Haematol Year: 2024 Document type: Article Affiliation country: Country of publication: