[Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of â©Lung Cancer].
Zhongguo Fei Ai Za Zhi
; 27(7): 529-534, 2024 Jul 20.
Article
in Zh
| MEDLINE
| ID: mdl-39147707
ABSTRACT
Lung cancer causes a significant threat to human health. Despite considerable advancements in the treatment technologies in recent years, the five-year survival rate for lung cancer patients remains low. In this context, the discovery of pyroptosis, a unique cell death mechanism, offers a novel perspective for exploring new pathways of lung cancer treatment. Particularly, the role of gasdermin E (GSDME) in the process of pyroptosis reveals its tremendous potential in lung cancer therapy. Recent studies have made considerable progress in understanding the role of GSDME-mediated pyroptosis in lung cancer growth, the lung cancer microenvironment, and the effect of GSDME methylation on lung cancer treatment. This paper summarizes these research advancements and analyzes the potential and possible side effects of GSDME-mediated pyroptosis in lung cancer therapy, aiming to provide a theoretical foundation for developing more effective strategies for lung cancer treatment.â©.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyroptosis
/
Lung Neoplasms
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Zhongguo Fei Ai Za Zhi
/
Zhongguo fei ai zazhi (Online)
/
Zhongguo fei'ai zazhi (Online)
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: