Rapid preparation of injectable dual-network hydrogels for biomedical applications using UV-triggered sulfhydryl click reactions.
Colloids Surf B Biointerfaces
; 244: 114180, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-39217728
ABSTRACT
The use of hydrogels to mimic natural cartilage implantation can effectively solve the current problems of insufficient cartilage donors and low rate of injury healing. In particular, injectable hydrogels are less invasive in clinical applications and better able to fill uneven injury surfaces. Here, we prepared NorCS and CS-SH by modifying chitosan with 5-norbornene-2-carboxylic acid and N-Acetyl-L-cysteine, respectively. Dual-network hydrogels were prepared by using UV-triggered thiol-ene click reaction between NorCS and CS-SH and the metal coordination between SA and Ca2+. The prepared hydrogels can be cross-linked quickly and exhibit excellent degradability, self-healing and injectable properties. At the same time, the hydrogel also showed good cytocompatibility and could significantly restore the motor function of mice. This study provides an effective strategy for preparing injectable hydrogels capable of rapid cross-linking.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfhydryl Compounds
/
Ultraviolet Rays
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Hydrogels
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Chitosan
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Click Chemistry
Limits:
Animals
Language:
En
Journal:
Colloids Surf B Biointerfaces
/
Colloids and surfaces
/
Colloids surf. B
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Country of publication: