APOE gene polymorphism in ischemic stroke patients from Huizhou and its correlation with blood lipids and homocysteine.
J Stroke Cerebrovasc Dis
; 33(11): 107990, 2024 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-39227003
ABSTRACT
OBJECTIVES:
To investigate the correlation between apolipoprotein E (APOE) gene polymorphisms and ischemic stroke and its relationship with blood lipids and homocysteine (HCY) level in Huizhou City. MATERIALS ANDMETHODS:
In this analytical cross-sectional study, we selected 2612 patients who underwent APOE genotyping from November 2019 to November 2021 at the Third People's Hospital of Huizhou. Among them, 2014 were ischemic stroke patients and 598 were non-stroke patients. The independent variables were ischemic stroke, different genotypes, and different alleles, while the dependent variables were blood lipid levels and HCY levels.RESULTS:
The distribution frequency of ε4 allele in stroke group was higher than that in non-stroke group (P < 0.05). Compared with ε4 allele carriers in the stroke group, the levels of lipid total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in ε2 and ε3 allele carriers were significantly lower, while the levels of high-density lipoprotein cholesterol (HDL-C) were significantly higher (P < 0.01). The levels of lipid Lipoprotein a (LPa) and small dense low-density lipoprotein (sdLDL) in ε2 allele carriers in stroke group were significantly lower than those of ε4 allele carriers (P < 0.05). Logistics regression analysis showed that age, TC, HCY level and allele ε4 were positively correlated with the risk of ischemic stroke (P < 0.01), TG level was positively correlated with the risk of ischemic stroke in females (P < 0.01).CONCLUSIONS:
APOE gene polymorphism is associated with ischemic stroke, and ε4 allele carriers have a higher risk than ε3 allele carriers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Stroke Cerebrovasc Dis
/
J. stroke cerebrovasc. dis
/
Journal of stroke and cerebrovascular diseases
Journal subject:
ANGIOLOGIA
/
CEREBRO
Year:
2024
Document type:
Article
Country of publication: