Case report: membranoproliferative glomerulonephritis associated with Q fever causing chronic endocarditis.
BMC Nephrol
; 25(1): 291, 2024 Sep 04.
Article
in En
| MEDLINE
| ID: mdl-39232673
ABSTRACT
BACKGROUND:
Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections. CASE PRESENTATION We herein present the case of a 62-year-old male patient who presented with fatigue and was found to have severe anemia, impaired renal function, and nephrotic syndrome. A renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) of the immune complex type with activation of the classical complement pathway. Further investigations led to the diagnosis of a chronic Coxiella burnetii-infection (Q fever), likely acquired during cycling trips in a region known for intensive sheep farming. Additionally, the patient was found to have a post endocarditic destructive bicuspid aortic valve caused by this pathogen. Treatment with hydroxychloroquine and doxycycline was administered for a duration of 24 months. The aortic valve was replaced successfully and the patient recovered completely.CONCLUSIONS:
Early detection and targeted treatment of this life-threatening disease is crucial for complete recovery of the patient.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Q Fever
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Glomerulonephritis, Membranoproliferative
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Endocarditis, Bacterial
Limits:
Humans
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Male
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Middle aged
Language:
En
Journal:
BMC Nephrol
Journal subject:
NEFROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: