The relationship between salivary cytokines and oral cancer and their diagnostic capability for oral cancer: a systematic review and network meta-analysis.
BMC Oral Health
; 24(1): 1044, 2024 Sep 05.
Article
in En
| MEDLINE
| ID: mdl-39237889
ABSTRACT
BACKGROUND:
Oral cancer (OC) is a common malignancy in clinical practice. Saliva testing is a convenient and noninvasive early diagnostic technique for OC. Several salivary cytokines have been identified as potential biomarkers for OC, including IL-8, IL-6, TNF-α, IL-1ß, and IL-10. Nonetheless, the optimal cytokine for OC diagnosis remains inconclusive and highly contentious.METHODS:
PubMed, Embase, Web of Science, and Cochrane Library databases were comprehensively retrieved to collect all case-control studies on OC. A meta-analysis was performed to compare the levels of salivary IL-8, IL-6, IL-10, TNF-α, and IL-1ß in OC patients and healthy controls. Network meta-analysis (NMA) was carried out to probe into the accuracy of these salivary cytokines in diagnosing OC.RESULTS:
This analysis included 40 studies, encompassing 1280 individuals with OC and 1254 healthy controls. Significantly higher levels of salivary IL-8, IL-6, TNF-α, IL-1ß, and IL-10 were observed in patients with OC in comparison to healthy controls. The results of NMA showed that TNF-α had the highest diagnostic accuracy for OC, with a sensitivity of 79% and a specificity of 92%, followed by IL-6 (sensitivity 75%, specificity 86%) and IL-8 (sensitivity 80%, specificity 80%).CONCLUSION:
This study suggests that IL-8, IL-6, IL-10, TNF-α, and IL-1ß may be potential diagnostic biomarkers for OC. Among them, TNF-α, IL-6, and IL-8 are highly accurate in the diagnosis of OC. Nevertheless, further studies that eliminate other confounding factors are warranted, and more standardized procedures and large-scale studies are needed to support the clinical use of saliva testing.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saliva
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Mouth Neoplasms
/
Biomarkers, Tumor
/
Cytokines
Limits:
Humans
Language:
En
Journal:
BMC Oral Health
/
BMC oral health
Journal subject:
ODONTOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: