Exploring the influence of non-coding RNAs on NF-κB signaling pathway regulation in ulcerative colitis.
Biomed Pharmacother
; 179: 117390, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39243424
ABSTRACT
The gastrointestinal tract is chronically inflamed in ulcerative colitis (UC), which has a complicated etiology involving immunological, environmental, and genetic factors. The inflammatory response that is typical of UC is significantly regulated via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Latest research has displayed that NF-κB signaling is controlled by three main types of non-coding RNAs (ncRNAs) circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). These ncRNAs can change the expression of key genes within the NF-κB pathway by acting as molecular sponges, transcriptional regulators, and epigenetic modifiers. This review synthesizes current knowledge on the functions by which ncRNAs modulate NF-κB signaling in UC, discusses their potential as biomarkers for disease prognosis and diagnosis, and explores their therapeutic potential. Understanding the intricate interactions between ncRNAs and NF-κB signaling may provide novel insights into UC pathogenesis and targeted therapeutic strategies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
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Colitis, Ulcerative
/
NF-kappa B
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Pharmacother
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: