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CD8+ tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis.
Feng, Xiao; Yu, Fan; He, Xin-Liang; Cheng, Pei-Pei; Niu, Qian; Zhao, Li-Qin; Li, Qian; Cui, Xiao-Lin; Jia, Zi-Heng; Ye, Shu-Yi; Liang, Li-Mei; Song, Lin-Jie; Xiong, Liang; Xiang, Fei; Wang, Xiao-Rong; Ma, Wan-Li; Ye, Hong.
Affiliation
  • Feng X; Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China.
  • Yu F; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • He XL; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Cheng PP; Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China.
  • Niu Q; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Zhao LQ; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Li Q; Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China.
  • Cui XL; Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China.
  • Jia ZH; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Ye SY; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Liang LM; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Song LJ; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Xiong L; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Xiang F; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Wang XR; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Ma WL; Department of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China.
  • Ye H; Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan, China.
Am J Physiol Cell Physiol ; 2024 Sep 09.
Article in En | MEDLINE | ID: mdl-39246141
ABSTRACT
Human tissue-resident memory T (TRM) cells play a crucial role in protecting the body from infections and cancers. Recent research observed increased numbers of TRM cells in the lung tissues of idiopathic pulmonary fibrosis patient. However, the functional consequences of TRM cells in pulmonary fibrosis remain unclear. Here, we found that the numbers of TRM cells, especially the CD8+ subset, were increased in the mouse lung with bleomycin-induced pulmonary fibrosis. Increasing or decreasing CD8+ TRM cells in mouse lungs accordingly altered the severity of fibrosis. In addition, adoptive transfer of CD8+ T cells containing a large number of CD8+ TRM cells from fibrotic lungs was sufficient to induce pulmonary fibrosis in control mice. Treatment with CCL18 to induced CD8+ TRM cell expansion and exacerbated fibrosis, while blocking CCR8 prevented CD8+ TRM recruitment and inhibited pulmonary fibrosis. In conclusion, CD8+ TRM cells are essential for bleomycin-induced pulmonary fibrosis, and targeting CCL18/CCR8/CD8+ TRM cells may be a potential therapeutic approach.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: