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The inflammaging clock strikes IL-11!
Khan, Saad; Chang, Veronica; Winer, Daniel A.
Affiliation
  • Khan S; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada.
  • Chang V; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Winer DA; Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: dwiner@buckinstitute.org.
Immunity ; 57(9): 2010-2012, 2024 Sep 10.
Article in En | MEDLINE | ID: mdl-39260354
ABSTRACT
Chronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Signal Transduction / Interleukin-11 / Inflammation Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Signal Transduction / Interleukin-11 / Inflammation Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: