[Enzymes of the detoxication of active forms of oxygen and lipoperoxides in experimental ischemia and myocardial infarct]. / Fermenty detoksikatsii aktivnykh form kisloroda i lipoperekissei pri éksperimental'noi ishemii i infarkte miokarda.
Biull Eksp Biol Med
; 93(5): 58-60, 1982 May.
Article
in Ru
| MEDLINE
| ID: mdl-7093510
ABSTRACT
Variation in the activity of superoxide dismutase, glutathione peroxidase (tretbutyl hydroperoxide as a substrate) and glutathione-S-transferase (1-chloro-2,4-dinitrobenzene as a substrate) was studied in rat ischemia and in coronaro-occlusion myocardial infarction. The activity of superoxide dismutase and glutathione peroxidase drastically reduced 2-15 minutes after ligation of the coronary artery and remained at the decreased level during the observation period (14 days). The activity of glutathione-S-transferase in the infarcted zone of the myocardium significantly decreased only by day 3 of the experiment. The activity of glutathione peroxidase in the blood of patients with acute myocardial infarction rose more than 1.5-fold.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen Consumption
/
Peroxidases
/
Superoxide Dismutase
/
Coronary Disease
/
Glutathione Peroxidase
/
Glutathione Transferase
/
Lipid Peroxides
/
Myocardial Infarction
Limits:
Animals
/
Humans
/
Male
/
Middle aged
Language:
Ru
Journal:
Biull Eksp Biol Med
Year:
1982
Document type:
Article