Decreased bactericidal activity during the period of the postantibiotic effect.
J Antimicrob Chemother
; 34(6): 921-30, 1994 Dec.
Article
in En
| MEDLINE
| ID: mdl-7730235
ABSTRACT
Standard and clinical strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae were subjected to continuous exposure to beta-lactams and aminoglycosides during the postantibiotic effect phase induced by rifampicin or erythromycin (for S. aureus). A significant inhibition of bactericidal activity by these agents during the PAE period was observed. The degree of inhibition was dependent both on the class of antimicrobial agent (beta-lactams > aminoglycosides) and the microorganism (Gram-negative bacilli > S. aureus).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteria
/
Microbial Sensitivity Tests
/
Drug Therapy, Combination
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
J Antimicrob Chemother
Year:
1994
Document type:
Article
Affiliation country: