Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.
J Infect Dis
; 172(1): 217-9, 1995 Jul.
Article
in En
| MEDLINE
| ID: mdl-7797914
ABSTRACT
Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing approximately 3300 pfu of virus. Of the subjects, 99% (414/419) maintained antibody to varicella zoster virus (VZV) with a geometric mean titer of 25.7 and mean stimulation index (SI) for VZV-specific lymphoproliferation response of 40.3 +/- 5.3 (SE). Some 7-10 days after the booster immunization, seropositivity rates increased to 100% (302/302), and GMT was 143.6 (anamnestic response). At 6 weeks after the booster inoculation, a subset of subjects had 100% seropositivity (74/74) with a GMT of 218.8 and an SI of 58.6. After 3 months, seropositivity was 100% (358/358), GMT was 119.0, and SI was 61.4.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines, Attenuated
/
Viral Vaccines
/
B-Lymphocytes
/
T-Lymphocytes
/
Immunization, Secondary
/
Herpesvirus 3, Human
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
J Infect Dis
Year:
1995
Document type:
Article
Affiliation country: