Mutagenicity of tetranitroazoxytoluenes: a preliminary screening in Salmonella typhimurium strains TA100 and TA100NR.
Mutat Res
; 335(3): 207-11, 1995 Dec.
Article
in En
| MEDLINE
| ID: mdl-8524334
ABSTRACT
Tetranitroazoxytoluenes are polynitroaromatic compounds that can be produced during the microbial reduction of the explosive, 2,4,6-trinitrotoluene (TNT). The three major tetranitroazoxytoluenes were synthesized and tested in Salmonella typhimurium strains TA100 and TA100NR. All compounds were mutagenic in TA100 but not in TA100NR, indicating the need for nitroreductase activity to induce mutagenicity. The most active chemical was 4,4',6,6'-tetranitro-2,2'-azoxytoluene (2735 rev/mumol) followed by 2',4,6,6'-tetranitro-2',4-azoxytoluene (929 rev/mumol) and 2,2'-6,6'-tetranitro-4,4'-azoxytoluene (320 rev/mumol). These chemicals were more active than the aminodinitrotoluenes (298 rev/mumol for 2-amino-4,6-dinitrotoluene and 115 rev/mumol for 4-amino-2,6-dinitrotoluene) and only 4,4',6,6'-tetranitro-2,2'-azoxytoluene was more active than the parent compound, TNT (1022 rev/mumol).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella typhimurium
/
Azo Compounds
/
Trinitrotoluene
/
Dinitrobenzenes
/
Mutagens
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
En
Journal:
Mutat Res
Year:
1995
Document type:
Article
Affiliation country: