Reactogenicity and immunogenicity of a three-component acellular pertussis vaccine administered as the primary series to 2, 4 and 6 month old infants in the United States.
Vaccine
; 13(17): 1631-5, 1995 Dec.
Article
in En
| MEDLINE
| ID: mdl-8719512
ABSTRACT
Five hundred and fifty-seven infants received either an acellular pertussis (DTaP) vaccine containing pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) or one of two commercially available whole-cell pertussis (DTP) vaccines at 2, 4 and 6 months. One month after the third immunization, IgG antibody values to pertussis toxoid, filamentous hemagglutinin and PRN were significantly greater following DTaP than either DTP (P < 0.05). When reactions within 48 h after all three doses of vaccine were combined, fever 101 degrees, > or = moderate fussiness, > or = moderate pain, swelling 10 mm, and erythema 10 mm occurred less often after DTaP compared with DTP-Connaught (P < 0.001). The same adverse events were also less after DTaP compared with DTP-Lederle (P < 0.05), except for erythema 10 mm. This three-component DTaP vaccine produced fewer adverse events and greater antibody values to PT, FHA and PRN in comparison with either licensed DTP vaccine when given as the primary series.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bordetella pertussis
/
Virulence Factors, Bordetella
/
Diphtheria-Tetanus-Pertussis Vaccine
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Vaccine
Year:
1995
Document type:
Article
Affiliation country: