Rôle of bile in the elimination of dipropyl sulphone from the male rat.

ABSTRACT

Following oral administration of [35S]-dipropyl sulphone to male Wistar rats (4.24 mmol/kg body wt), the only radioactive component subsequently found in the blood and bile was the sulphone. Biliary excretion played an important rôle in the elimination of this compound, with 16% of the dose excreted during the first twenty-four hours and 33% passing through the bile duct over a two day period. Bile/plasma concentration ratios remained constant during the first day (c. 46-fold), suggesting that a concentration process was taking place and that active transport of this low molecular weight compound (150 Da) into the bile was occurring.