The kinetics of anterior chamber ofloxacin penetration.
Cornea
; 15(1): 72-5, 1996 Jan.
Article
in En
| MEDLINE
| ID: mdl-8907384
ABSTRACT
Thirty-five patients received topical ofloxacin 0.3% before routine cataract surgery. Ofloxacin was administered one drop every 2 h for five doses 1 day before surgery and one drop every 5 min for five doses immediately before surgery. Aqueous sampling was performed at variable periods 30-150 min after the last topical dose. The mean aqueous ofloxacin concentration was 793 +/- 516 ng/ml (range, 143-2,400 ng/ml). A significant correlation between time from last dose and aqueous humor concentration was found (r = 0.39, p = 0.025). The mean ofloxacin concentration was greater in those patients who received their last dose >1 h before aqueous aspiration (957 +/- 559 ng/ml versus 554 +/- 338 ng/ml, p = 0.02). From a best-fit scatter plot of concentration versus time, the maximal aqueous concentration of 1,000 ng/ml occurs at approximately 2h after topical administration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ofloxacin
/
Anterior Chamber
Limits:
Humans
Language:
En
Journal:
Cornea
Year:
1996
Document type:
Article
Affiliation country: