Targeting gene expression to hypoxic tumor cells.
Nat Med
; 3(5): 515-20, 1997 May.
Article
in En
| MEDLINE
| ID: mdl-9142119
ABSTRACT
Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Phosphoglycerate Kinase
/
Transcription Factors
/
Nuclear Proteins
/
Gene Expression Regulation, Neoplastic
/
DNA-Binding Proteins
/
Fibrosarcoma
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Med
Journal subject:
BIOLOGIA MOLECULAR
/
MEDICINA
Year:
1997
Document type:
Article
Affiliation country: