Resource competition as a mechanism for B cell homeostasis.
Proc Natl Acad Sci U S A
; 94(11): 5792-7, 1997 May 27.
Article
in En
| MEDLINE
| ID: mdl-9159153
ABSTRACT
Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
Bone Transplantation
/
Models, Immunological
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
1997
Document type:
Article
Affiliation country: