Brucella abortus siderophore 2,3-dihydroxybenzoic acid protects brucellae from killing by macrophages.
Vet Res
; 28(1): 87-92, 1997.
Article
in En
| MEDLINE
| ID: mdl-9172844
ABSTRACT
Addition of 2,3-dihydroxybenzoic acid, a siderophore produced by Brucella abortus, to macrophage cultures prevented intracellular killing of brucellae during the first 12 h after infection and increased the number of intracellular brucellae recovered at 48 h after infection. The protective effect could be demonstrated with inflammatory macrophages, interferon-gamma-activated macrophages and with macrophages supplemented with iron, shown elsewhere to facilitate killing of B abortus.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brucella abortus
/
Siderophores
/
Macrophages, Peritoneal
/
Hydroxybenzoates
Limits:
Animals
Language:
En
Journal:
Vet Res
Journal subject:
MEDICINA VETERINARIA
Year:
1997
Document type:
Article
Affiliation country: