Infant immunization with pneumococcal CRM197 vaccines: effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines.
J Infect Dis
; 176(2): 445-55, 1997 Aug.
Article
in En
| MEDLINE
| ID: mdl-9237711
ABSTRACT
Six pentavalent pneumococcal conjugate vaccines (Pn-CRM197) were evaluated among 400 infants. The vaccines differed in saccharide chain length (oligosaccharide [OS] or polysaccharide [PS]) and saccharide quantity (0.5, 2, or 5 microg). Subjects were randomized into groups 1-6 (Pn-CRM197 recipients) or 7 (controls) for immunization at 2, 4, and 6 months of age. Pn-CRM197 were well tolerated and elicited mean antibody concentrations that exceeded those in controls for all 5 capsular serotypes. PS formulations were generally more immunogenic than their OS counterparts. For PS vaccines, a dose-response was documented (5 microg > 2 microg > 0.5 microg), but the differences between the 5- and 2-microg formulations were insignificant. The mean anti-PRP antibody concentration was significantly higher among Pn-CRM197 recipients. It is concluded that PS vaccines are more immunogenic than OS vaccines. The improved immunogenicity from Haemophilus type b oligosaccharide conjugate (HbOC) vaccine when given with Pn-CRM197 suggests that a decreased dose of HbOC vaccine may be sufficient to elicit protection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligosaccharides
/
Polysaccharides, Bacterial
/
Streptococcus pneumoniae
/
Bacterial Proteins
/
Bacterial Vaccines
/
Haemophilus Vaccines
/
Antibodies, Bacterial
Type of study:
Clinical_trials
Limits:
Humans
/
Infant
Language:
En
Journal:
J Infect Dis
Year:
1997
Document type:
Article
Affiliation country: