Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: evidence for preferential expansion of Th-2 cells.
Cytokines Mol Ther
; 2(1): 59-65, 1996 Mar.
Article
in En
| MEDLINE
| ID: mdl-9384690
ABSTRACT
Liposomes have been used to modify the immunological behaviour of a number of antigens. The present study was designed to evaluate the effect of liposomization of ovalbumin on the induction of Th-1 and Th-2-cell response by monitoring the secretion of lymphokines and IgG Isotypes. Liposomes having varied physicochemical properties (positively and negatively charged, neutral and pH-sensitive) were used for this purpose. Ovalbumin delivered in this way induced preferential secretion of IL-4 and production of antigen-specific IgG1 isotypes. This was observed irrespective of the surface charge properties of the liposomes. Further, the concentration of antigen required for the activation of Th cells was 10(2)- to 10(3)-fold lower after encapsulating it in liposomes. These results suggest that liposomes may prove useful adjuvants to prime Th2-like immune responses.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin Isotypes
/
Immunoglobulin G
/
CD4-Positive T-Lymphocytes
/
Ovalbumin
/
Lymphokines
/
Interleukin-4
/
Th2 Cells
/
Antigens
Limits:
Animals
Language:
En
Journal:
Cytokines Mol Ther
Journal subject:
ALERGIA E IMUNOLOGIA
/
BIOLOGIA MOLECULAR
Year:
1996
Document type:
Article
Affiliation country: