Thrombosis in congenital deficiencies of AT III, protein C or protein S: a study of 44 children.
Hematol Cell Ther
; 39(6): 295-9, 1997 Dec.
Article
in En
| MEDLINE
| ID: mdl-9497888
ABSTRACT
Congenital deficiency in coagulation inhibitors is a cause of hereditary thrombotic disease. The severity of symptoms is variable and depends on the type of deficit. In this paper, 44 children suffering from deep venous thrombosis, with a mean age of 5 years, were studied. A search for Lupus anticoagulant (LA) and coagulation inhibitor deficiency showed 3/44 cases (6.8%) had protein S deficiency, 2/44 cases (4.5%) had protein C deficiency, 1/44 cases (2.3%) had deficiencies in both protein C and S; no cases of AT III deficiency and LA was positive in 2/44 cases (4.5%). Only 1 case of APC resistance out of 13 studied was found. Four family studies were performed and confirmed the congenital origin of the disorder.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombophlebitis
/
Protein S Deficiency
/
Blood Coagulation Factor Inhibitors
/
Antithrombin III Deficiency
/
Protein C Deficiency
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
Hematol Cell Ther
Journal subject:
HEMATOLOGIA
Year:
1997
Document type:
Article
Affiliation country: