Increased LFA-1 expression in intestines of rats with GVHD after small bowel transplantation.
Dig Dis Sci
; 43(2): 221-8, 1998 Feb.
Article
in En
| MEDLINE
| ID: mdl-9512110
ABSTRACT
Experimental graft-versus-host disease (GVHD) causes immune-mediated intestinal injury. The adhesion molecule lymphocyte function associated antigen-1 (LFA-1) is involved in leukocyte homing to areas of inflammatory injury. Our hypothesis was that LFA-1 is increased in the GVHD injured small bowel and colon. We found that animals with GVHD caused by auxiliary small bowel transplantation displayed significantly increased expression of intestinal LFA-1alpha at times of clinical illness when compared to controls. The staining pattern progressed from a few discretely stained cells in the lamina propria on day 5 to diffuse confluent staining of lamina propria on day 13 and was statistically significantly increased from controls at days 10 and 13. CyA-treated animals had intermediate staining between control and day 13 GVHD animals. There was no difference between sham-operated control animals and SBTx animals with GVHD in the amount of staining for LFA-1 in extraintestinal organs normally affected by GVHD. We conclude that (1) LFA-1 expression in the small bowel and colon progressively increased during GVHD after SBTx; and (2) CyA treatment is associated with decreased LFA-1 expression in the small bowel and colon of GVHD animals after SBTx. LFA-1 may play an important role in immune-mediated injury of the intestine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Function-Associated Antigen-1
/
Graft vs Host Disease
/
Intestine, Small
Limits:
Animals
Language:
En
Journal:
Dig Dis Sci
Year:
1998
Document type:
Article
Affiliation country: