[Endothelial dysfunction in cardial failure: potential mechanisms]. / Dysfonction endothéliale dans l'insuffisance cardiaque: mécanismes potentiels.
Arch Mal Coeur Vaiss
; 90 Spec No 6: 29-34, 1997 Nov.
Article
in Fr
| MEDLINE
| ID: mdl-9515111
ABSTRACT
From the vascular point of view, cardiac failure is characterised by increased systemic resistances secondary to an increased concentration of a number of vasoconstrictor substances and also to decreased endothelium dependent vasodilatation. Endothelial dysfunction has been described both in man and in animal models, but its causes are not well understood. Such dysfunction could be due to a decrease in the production of nitric oxide, a decrease in its vasodilator effect due to an increased degradation or an increased vasoconstrictor tone. Recent data suggests an improvement or prevention of this endothelial dysfunction observed in cardiac failure by physical training and by chronic treatment with an angiotensin converting enzyme inhibitor. The improvement or preservation of endothelial function induced by exercise or ACE inhibitor could explain some of the benefits of these treatments in terms of tissue perfusion and haemodynamic conditions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelium, Vascular
/
Heart Failure
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Arch Mal Coeur Vaiss
Year:
1997
Document type:
Article