mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit.
Neurosci Lett
; 239(1): 49-53, 1997 Dec 12.
Article
in En
| MEDLINE
| ID: mdl-9547169
ABSTRACT
The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced. It showed a 90% nucleotide conservation when compared to the rodent homologue. GRIN2B gene is expressed at high levels in the fronto-parieto-temporal cortex and hippocampus pyramidal cells and, at a lower extent, in the basal ganglia (amygdala and striatum). The cerebellar granule cells does not show any mRNA expression. The non-ubiquitous anatomical distribution of the GRIN2B mRNA in the central nervous system suggests that the gene could be involved in specific functions pertaining to the expressing cell groups.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Brain Chemistry
/
RNA, Messenger
/
Receptors, N-Methyl-D-Aspartate
Limits:
Adult
/
Humans
Language:
En
Journal:
Neurosci Lett
Year:
1997
Document type:
Article
Affiliation country: