Dimeric inhibin serum values as markers of ovarian activity in pill-free intervals.
Contraception
; 57(1): 45-8, 1998 Jan.
Article
in En
| MEDLINE
| ID: mdl-9554250
ABSTRACT
PIP: Serum values of dimeric inhibin A and B were measured to assess the restoration of pituitary and ovarian activity during the pill-free interval in women taking combined oral contraceptives. 175 healthy women 18-35 years of age from five areas in Belgium were enrolled and monitored during routine gynecologic examinations. During the 7 day pill-free interval, inhibin B levels rose significantly in parallel with rising levels of follicle-stimulating hormone, luteinizing hormone, and estradiol. Progesterone levels were completely suppressed. Inhibin A levels rose slightly but insignificantly, reflecting an absence of development of preovulatory follicles. These findings indicate that inhibins are sensitive biochemical markers of ovarian activity in pill-free intervals. Inhibin B appears to be predominantly a product of the cohort of developing primary and subsequent early antral follicles, while inhibin A secretion is more indicative of dominant follicular and corpus luteum function.
Key words
Belgium; Biology; Clinical Research; Contraception; Contraceptive Methods--pharmacodynamics; Developed Countries; Endocrine System; Europe; Family Planning; Genitalia; Genitalia, Female; Hormones; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Ovarian Effects; Ovary; Physiology; Pituitary Hormones; Research Methodology; Research Report; Urogenital System; Western Europe
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progestins
/
Estradiol Congeners
/
Ethinyl Estradiol
/
Ovarian Follicle
/
Inhibins
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Contraception
Year:
1998
Document type:
Article
Affiliation country:
Country of publication: