Autoradiographic localisation of muscarinic cholinergic receptor subtypes in human placenta.
Neurosci Lett
; 247(2-3): 167-70, 1998 May 15.
Article
in En
| MEDLINE
| ID: mdl-9655619
ABSTRACT
The localisation of M1-M4 muscarinic cholinergic receptor subtypes was investigated in sections of normal human term placenta by light microscope autoradiography. Muscarinic cholinergic receptor subtypes were found almost exclusively in syncytiotrophoblast. Neither other cellular components of placenta, nor blood vessels were labelled. Quantitative analysis of the density of silver grains developed in sections incubated with the different protocols for labelling M1-M4 receptor subtypes, revealed that syncytiotrophoblast expresses all subtypes of muscarinic cholinergic receptor investigated. A higher density of binding sites was found in the apical than in the basal portion of syncytiotrophoblast. The demonstration of muscarinic cholinergic receptors in syncytiotrophoblast suggests that a cholinergic system may have a role in regulating transport of compounds from maternal to foetal interface.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placenta
/
Receptors, Muscarinic
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Neurosci Lett
Year:
1998
Document type:
Article
Affiliation country: