Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study.
Mech Ageing Dev
; 102(2-3): 187-98, 1998 May 15.
Article
in En
| MEDLINE
| ID: mdl-9720651
ABSTRACT
Results from a previous longitudinal study indicated that a combination of high CD8 and low CD4 percentages and poor T cell proliferation in peripheral blood lymphocytes was associated with higher mortality in a subgroup of a sample of very old Swedish individuals. The present study examined whether those results could be confirmed at a subsequent 2-year time interval by investigating if additional individuals from the same original sample had developed the immune profile associated with higher mortality. Subgroups were formed by cluster analysis and similar to our previous results, this follow-up study identified a subgroup of subjects (n = 18) with an immune profile which again included high CD8, low CD4 percentages and poor mitogen response and was associated with higher mortality. Over the 2-year period 12 additional individuals (1) Developed this immune profile; and (2) Could be identified by changes in their CD4CD8 ratios which progressively decreased over the study period. These results confirm our original study and indicate that in this very old sample, over a subsequent 2 year period, additional individuals moved into the cluster at risk for higher mortality.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
CD4-Positive T-Lymphocytes
/
CD8-Positive T-Lymphocytes
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Mech Ageing Dev
Year:
1998
Document type:
Article
Affiliation country: