Fusion-competent vaccines: broad neutralization of primary isolates of HIV.
Science
; 283(5400): 357-62, 1999 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-9888845
ABSTRACT
Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, "fusion-competent" HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E. Development of these fusion-dependent immunogens may lead to a broadly effective HIV vaccine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Antibodies
/
HIV Antigens
/
Gene Products, env
/
HIV-1
/
AIDS Vaccines
Limits:
Animals
/
Humans
Language:
En
Journal:
Science
Year:
1999
Document type:
Article
Affiliation country: