Research progress on the roles of neurovascular unit in stroke-induced immunosuppression / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 662-672, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1009926
Responsible library:
WPRO
ABSTRACT
A complex pathophysiological mechanism is involved in brain injury following cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly participates in the regulation of inflammatory immune process. The components of NVU promote inflammatory overreaction and synergize with the overactivation of autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID can alleviate the damage caused by inflammation, however, it also makes stroke patients more susceptible to infection, leading to systemic damage. This article reviews the mechanism of SIID and the roles of NVU in SIID, to provide a perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral infarction.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Cerebral Infarction
/
Immunosuppression Therapy
/
Stroke
/
Endothelial Cells
/
Neurons
Limits:
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2023
Document type:
Article