Thirteen new peptaibols with antimicrobial activities from Trichoderma sp / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 868-880, 2023.
Article
in En
| WPRIM
| ID: wpr-1010998
Responsible library:
WPRO
ABSTRACT
From the fungus Trichoderma sp., we isolated seven novel 18-residue peptaibols, neoatroviridins E-K (1-7), and six new 14-residue peptaibols, harzianins NPDG J-O (8-13). Additionally, four previously characterized 18-residue peptaibols neoatroviridins A-D (14-17) were also identified. The structural configurations of the newly identified peptaibols (1-13) were determined by comprehensive nuclear magnetic resonance (NMR) and high-resolution electrospray ionization tandem mass spectrometry (HR-ESI-MS/MS) data. Their absolute configurations were further determined using Marfey's method. Notably, compounds 12 and 13 represent the first 14-residue peptaibols containing an acidic amino acid residue. In antimicrobial assessments, all 18-residue peptaibols (1-7, 14-17) exhibited moderate inhibitory activities against Staphylococcus aureus 209P, with minimum inhibitory concentration (MIC) values ranging from 8-32 μg·mL-1. Moreover, compound 9 exhibited moderate inhibitory effect on Candida albicans FIM709, with a MIC value of 16 μg·mL-1.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Trichoderma
/
Spectrometry, Mass, Electrospray Ionization
/
Tandem Mass Spectrometry
/
Peptaibols
/
Anti-Infective Agents
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2023
Document type:
Article