Effect of intensive rosuvastatin calcium combined with clopidogrel and aspirin on patients with high risk of transient ischemic attack / 中风与神经疾病杂志

ABSTRACT

@#Objective　To explore the clinical efficacy of intensive rosuvastatin calcium combined with clopidogrel and aspirin on patients with high risk of transient ischemic attack （TIA）,and the influence of treatment on carotid artery intima-media thickness,blood lipid and platelet parameter.Methods　One hundred and ten patients with high risk of TIA were randomly divided into control group and treatment group.The control group was given rosuvastatin 10 mg/d combined with 100 mg/d aspirin (withdraw at day 21) and 75 mg/d clopidogrel,while the treatment group was initiated with a loading dose of 20 mg/d for 14 days followed by 10 mg/d combined with 100 mg/d aspirin (withdraw at day 21) and 75 mg/d clopidogrel.The primary efficacy end point is the percentage of patients with any stroke,the influence on carotid artery intima-media thickness,blood lipid and platelet parameter 3 months later.Results　Stroke occurred in 5.2% of patients in the treatment group and 11.5% in the control group,the difference was statistically significantly (P<0.05).Total cholesterol (TC),triglyceride (TG),and low density lipoprotein-C (LDL-C) were significant lower in treatment group compared with those in control group,and the difference was statistically significantly (P<0.05).The carotid artery intima-media thickness was lower in the treatment group (P<0.05).Besides,the platelet (PLT) count and the mean platelet volume (MPV) was lower after treatment (P<0.05).Moreover,MPV were significantly lower in treatment group compared to that in control group 3 months later (P<0.05).Conclusion　Intensive rosuvastatin calcium combined with clopidogrel and aspirin can reduce the blood lipid level and has a significant effect on the prevention of patients with high risk of TIA to cerebral infarction,reduce the carotid artery intima-media thickness,PLT and MPV.