Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy
Korean Journal of Radiology
; : 1153-1162, 2015.
Article
in En
| WPRIM
| ID: wpr-163287
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). MATERIALS ANDMETHODS:
Fifty-nine patients with DCM (mean age, 55 +/- 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients.RESULTS:
The mean LV ejection fraction was 24 +/- 9% and the post-T1 value was 254.5 +/- 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (beta = -0.351, p = 0.016) and the LV mass/volume ratio (beta = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (beta = -0.339, p = 0.017).CONCLUSION:
Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.Key words
Full text:
1
Database:
WPRIM
Main subject:
Peptide Fragments
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Blood Pressure
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Algorithms
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Magnetic Resonance Imaging
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Echocardiography
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Cardiomyopathy, Dilated
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Multivariate Analysis
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Natriuretic Peptide, Brain
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Ventricular Remodeling
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Extracellular Space
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Korean Journal of Radiology
Year:
2015
Document type:
Article