Progress on matrix metalloproteinase in axonal regeneration / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 95-100, 2015.
Article
in Zh
| WPRIM
| ID: wpr-255227
Responsible library:
WPRO
ABSTRACT
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. MMPs can degrade and remodel extracellular matrix, also active or inactive many molecules attaching to matrix including receptors, growth factors and cytokines, so that injury-induced MMPs can change the extracellular environment to affect the axonal regeneration in central nervous system. In this review, with spinal cord injury (SCI) as an example we discuss the effects of MMPs on inflammation, neuronal viability, extracellular molecules, glial scar and axonal remyelination, which are all important to axonal regeneration.
Full text:
1
Database:
WPRIM
Main subject:
Spinal Cord Injuries
/
Axons
/
Neuroglia
/
Cicatrix
/
Matrix Metalloproteinases
/
Extracellular Matrix
/
Nerve Regeneration
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2015
Document type:
Article