Bilateral regulatory action of corticotropin-releasing hormone on immune-mediated inflammation / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 350-354, 2009.
Article
in En
| WPRIM
| ID: wpr-272964
Responsible library:
WPRO
ABSTRACT
In trauma, infection and hemorrhagic shock derived stress, primary and secondary injury may result in severe derangement in the internal environment. The abnormal changes of immune-mediated inflammation interfere its pathogenesis and development directly. In recent years, various aspects of neuroendocrine responses, especially the regulatory effects of hypothalamic-pituitary-adrenal and sympathetico-adrenomedullary axes in inflammatory diseases have been the focus of research. Most importantly, corticotropin-releasing hormone (CRH) acts as a key player in the regulation of interactions between neuroendocrine and immunity both directly and indirectly. The paper summarized the recent development of CRH in the immune-mediated inflammation.
Full text:
1
Database:
WPRIM
Main subject:
Physiology
/
Corticotropin-Releasing Hormone
/
Chemistry
/
Allergy and Immunology
/
Genetics
/
Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Chinese Journal of Traumatology
Year:
2009
Document type:
Article