Ubiquitination of recombinant adeno-associated viral vector and its application / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 586-591, 2012.
Article
in Zh
| WPRIM
| ID: wpr-336747
Responsible library:
WPRO
ABSTRACT
Recombinant adeno-associated virus (rAAV) has been widely used as vector for gene therapy. However, the effectiveness of gene therapy based on rAAV needs to be further improved. Enhancement of the transduction efficiency is one of the most important fields for rAAV-based gene therapy. Recent results have showed that the ubiquitin-proteasome system plays an important role in the trafficking of rAAV vector in cytoplasm, and regulation of its function may significantly improve the transduction efficiency of rAAV vector in various types of cells and tissues.
Full text:
1
Database:
WPRIM
Main subject:
Transduction, Genetic
/
Dependovirus
/
Ubiquitin
/
Genetic Vectors
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Document type:
Article