Research Progress in Focal Adhesion Kinase Used for Neurological Diseases / 中国药师

ABSTRACT

Focal adhesion kinase ( FAK) is one of novel non-receptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures,which is activated through the phosphorylation of its tyrosine residue by ligands that bind to integrins. Some studies have demonstrated that FAK has close relationship with nervous system development, synaptic plasticity and the occurrence and development of nervous system diseases. The review summarized the functions of FAK in neurological diseases.