Expression of LMP2A, E-Cadherin and fibronectin in nasopharyngeal carcinoma and its clinical significance / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 132-136, 2015.
Article
in Zh
| WPRIM
| ID: wpr-748763
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of EBV-encoded latent membrane protein 2A (LMP2A) and epithelial-mesenchymal transformation(EMT) associated markers (E-cadherin and fibronectin) in nasopharyngeal carcinoma (NPC) and its clinical significance.@*METHOD@#The expression of LMP2A, E-cad-herin and fibronectin proteins in 32 cases of chronic nasopharyngeal inflammation, 56 cases of NPC and 18 cases of NPC lymph node metastasis were examined byimmunohistochemical SP method.@*RESULT@#(1)The positive rates of LMP2A in NPC and its lymph node metastasis were significantly higher than those of chronic nasopharyngeal inflammation (89. 3%vs 37. 5%o and 77. 8% vs 37. 5%) respectively (both P 0. 05). In addition, LMP2A and E-cadherin expression were significantly correlated with T stage (both P<0. 01).@*CONCLUSION@#LMP2A and fibronectin expressions were increased in NPC, but normal expression of E-cadherin were decreased. LMP2A may promote lymph node metastasis and malignant progression of NPC by induce EMT through downregulation of E-cadherin and upregulation of fibronectin.
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Carcinoma
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Cadherins
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Nasopharynx
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Nasopharyngeal Neoplasms
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Fibronectins
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Epithelial-Mesenchymal Transition
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Nasopharyngeal Carcinoma
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Lymphatic Metastasis
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Membrane Proteins
Limits:
Humans
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Document type:
Article