Expression and significance of p53 and mdm2 in patients with leukoplakia cancer
Asian Pacific Journal of Tropical Medicine
; (12): 831-834, 2013.
Article
in En
| WPRIM
| ID: wpr-819961
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the relationship of the expressions of p53 and mdm2 in leukoplakia cancer.@*METHODS@#RT-PCR was used to detect the mRNA of p53, mdm2 in patients with leukoplakia cancer. The frequencies of p53, mdm2 in peripheral blood were detected by flow cytometric analysis.@*RESULTS@#The expression of p53mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 7.7%, 27.3%,33.3%, 56.8%, respectively. The frequencies of p53 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.3±0.1)%, (1.6±0.9)%, (1.9±1.1)%, (3.4±1.8)%. The expression of mdm2 mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 0.0%, 6.8%, 11.1%, 37.8%, respectively. The frequencies of mdm2 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.1±0.1)%, (0.8±0.6)%, (1.2±0.8)%, (1.2±0.8)%. There was a positively correlation between p53 mRNA and mdm2 mRNA.@*CONCLUSIONS@#The positive rate of p53 and mdm2 cells in the peripheral blood increases in patients with leukoplakia cancer tissue and has positive correlation with the severity of leukoplakia cancer.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Gene Expression Regulation, Neoplastic
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Tumor Suppressor Protein p53
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Proto-Oncogene Proteins c-mdm2
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Genetics
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Leukoplakia
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Metabolism
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
En
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Document type:
Article