Meta-analysis of Ganmao Qingre Granules in treatment of children with wind-cold syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3292-3298, 2020.
Article
in Zh
| WPRIM
| ID: wpr-828445
Responsible library:
WPRO
ABSTRACT
To systematically evaluate the efficacy and safety of Ganmao Qingre Granules in treatment of children with wind-cold syndrome. The study systematically retrieved CNKI, WanFang, VIP, CBM, PubMed, EMbase and Cochrane Library for children cases with wind-cold syndrome treated with RCT. The literature inclusion criteria provided by Cochrane was used to evaluate the litera-ture quality, and Meta-analysis was conducted by RevMan 5.3 software. A total of 6 literatures were included, with a total sample size of 492 cases, including 246 cases in the experimental group and 246 cases in the control group. According to the results of Meta-analysis, the experimental group recorded the hypothermia time(MD=-0.38, 95%CI[-0.53,-0.23], P<0.01), the total clinical effective rate(RR=1.25, 95%CI[1.15, 1.36], P<0.01), the cough relief time(MD=-2.75, 95%CI[-3.05,-2.46], P<0.01), the decrease nasal congestion relief time(MD=-1.45, 95%CI[-1.69,-1.22], P<0.01), traditional Chinese medicine syndrome score(MD=-8.35, 95%CI[-9.35,-7.36], P<0.01), all of them were superior to those of the control group(Aminophenol Huangnamin Granules), with statistically significant differences. Only 2 literatures mentioned no obvious adverse reaction, and the other 4 literatures did not mention any adverse reactions. Based on the results of this study, it was indicated that Ganmao Qingre Granules were effective in the treatment of children with wind-cold syndrome, but with unclear adverse reactions. Due to the insufficient quantity and low quality of included literatures, the efficacy and safety need to be further confirmed by more high-quality clinical studies.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Syndrome
/
Wind
/
Drugs, Chinese Herbal
/
Cough
/
Medicine, Chinese Traditional
Type of study:
Diagnostic_studies
/
Systematic_reviews
Limits:
Child
/
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2020
Document type:
Article