Level of Microparticles in Patients with Essential Thrombocythemia and Its Relation with JAK2V617F Mutation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 2046-2050, 2020.
Article
in Zh
| WPRIM
| ID: wpr-880013
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To detect the levels of microparticles (MP) in plasma of patients with esseutial thrombo-cythermia(ET) and analyze the relationship between the JAK2V617F mutant and MP in ET patients.@*METHODS@#The numerical values of MPs were analysed by using flow cytometry. Venous blood of 56 ET patients and 28 healthy persons was collected in the morning and anticoagulated with sodium citrate (1∶9). The RMP, PMP, TF@*RESULTS@#The detection results showed that the MP levels in ET group were higher than those in normal control group: RMP (157.2±304.9/μl vs 21.3±18.4/μl), PMP (1378.9±2454/μl vs 113.8±97.1/μl), TF@*CONCLUSION@#The numerical values of MP detected are more in ET patients than those in healthy controls. The number of MP is higher in patients with thrombus than that without thrombus, so do in patients with splenomegaly and without splenomegaly. Patients with JAK2V617F mutation show higher number of TF
Full text:
1
Database:
WPRIM
Main subject:
Patients
/
Blood Platelets
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Endothelial Cells
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Cell-Derived Microparticles
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Thrombocythemia, Essential
/
Mutation
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2020
Document type:
Article