Changes in the Cytokine Profiles of Patients with Chronic Hepatitis B during Antiviral Therapy / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 443-453, 2021.
Article
in En
| WPRIM
| ID: wpr-887715
Responsible library:
WPRO
ABSTRACT
Objective@#To investigate the changes in the cytokine profiles of chronic hepatitis B (CHB) patients undergoing antiviral treatment.@*Methods@#Hepatitis B e antigen (HBeAg)-positive patients were treated with Pegylated interferon (PEG-IFN) and entecavir (ETV). Clinical biochemistry and cytokines were detected at baseline and every 3 months.@*Results@#In all, 200 patients completed 48 weeks of treatment, 100 in the PEG-IFN group and 100 in the ETV group. During 3-6 months of treatment, compared with baseline, the PEG-IFN group showed a significant decrease in interferon-gamma (IFN-γ), interleukin-17A (IL-17A), interleukin-6(IL-6), interleukin-10(IL-10), and transforming growth factor beta (TGF-β) ( @*Conclusion@#During antiviral therapy, a change in the cytokine profile occurred; in the aspect of immune control and functional cure, PEG-IFN was significantly better than ETV.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Antiviral Agents
/
Polyethylene Glycols
/
Recombinant Proteins
/
Prospective Studies
/
Cytokines
/
Interferon-alpha
/
Hepatitis B, Chronic
/
Guanine
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2021
Document type:
Article