The effects of heroin on intracellular free Ca2+ of rat myocardium / 法医学杂志
Journal of Forensic Medicine
; (6): 424-427, 2007.
Article
in Zh
| WPRIM
| ID: wpr-983331
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effects of heroin on intracellular free Ca2+ in rat myocardium.@*METHODS@#The effects of heroin on intracellular free Ca2+ were observed in cultured neonatal rat myocardium by measuring intracellular free Ca2+ concentration using calcium fluorescent probe Flou-3/AM and laser scanning confocal microscope.@*RESULTS@#Different doses and concentrations of heroin appeared to have different effects on intracellular free Ca2+ concentrations, with a dosage dependent short linear increase in the fluorescence intensity (i.e., Ca2+ concentration) leading to [Ca2+]i peak.@*CONCLUSION@#Heroin could affect concentrations of [Ca2+]i in myocardium and its dosage related effect needs further investigation.
Full text:
1
Database:
WPRIM
Main subject:
Cells, Cultured
/
Calcium
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Rats, Sprague-Dawley
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Microscopy, Confocal
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Calcium Signaling
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Myocytes, Cardiac
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Heroin
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Dose-Response Relationship, Drug
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Microscopy, Fluorescence
Limits:
Animals
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2007
Document type:
Article