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Higher values of triglycerides: HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia
Teixeira, R S; Arriaga, M B; Terse-Ramos, R; Ferreira, T A; Machado, V R; Rissatto-Lago, M R; Silveira-Mattos, P S; Boa-Sorte, N; Ladeia, A M T; Andrade, B B.
Affiliation
  • Teixeira, R S; Escola Bahiana de Medicina e Saúde Pública. Salvador. BR
  • Arriaga, M B; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador. BR
  • Terse-Ramos, R; Universidade Federal da Bahia. Departamento de Pediatria, Faculdade de Medicina. Salvador. BR
  • Ferreira, T A; Universidade Federal da Bahia. Departamento de Pediatria, Faculdade de Medicina. Salvador. BR
  • Machado, V R; Escola Bahiana de Medicina e Saúde Pública. Salvador. BR
  • Rissatto-Lago, M R; Universidade Estadual da Bahia. Departamento de Ciências da Vida. Salvador. BR
  • Silveira-Mattos, P S; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador. BR
  • Boa-Sorte, N; Escola Bahiana de Medicina e Saúde Pública. Salvador. BR
  • Ladeia, A M T; s.af
  • Andrade, B B; Escola Bahiana de Medicina e Saúde Pública. Salvador. BR
Braz. j. med. biol. res ; 52(10): e8833, 2019. tab, graf
Article in En | LILACS | ID: biblio-1039248
Responsible library: BR1.1
ABSTRACT
Dyslipidemia has been described in sickle cell anemia (SCA) but its association with increased disease severity is unknown. Here, we examined 55 children and adolescents with SCA as well as 41 healthy controls to test the association between the lipid profiles in peripheral blood and markers of hemolysis, inflammation, endothelial function, and SCA-related clinical outcomes. SCA patients exhibited lower levels of total cholesterol (P<0.001), low-density lipoprotein cholesterol (LDL-c) (P<0.001), and high-density lipoprotein cholesterol (HDL-c) (P<0.001), while displaying higher triglyceride (TG) levels and TG/HDL-c ratio values (P<0.001). TG/HDL-c values were positively correlated with lactate dehydrogenase (P=0.047), leukocyte count (P=0.006), and blood flow velocity in the right (P=0.02) and left (P=0.05) cerebral artery, while being negatively correlated with hemoglobin levels (P<0.04). Acute chest syndrome (ACS) and vaso-occlusive events (VOE) were more frequent in SCA patients exhibiting higher TG/HDL-c values (odds ratio 3.77, P=0.027). Multivariate logistic regression analysis confirmed independent associations between elevated TG/HDL-c values and SCA. Thus, children and adolescents with SCA exhibited a lipid profile associated with hemolysis and inflammatory parameters, with increased risk of ACS and VOE. TG/HDL-c is a potential biomarker of severity of disease.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Anemia, Sickle Cell / Cholesterol, HDL Type of study: Observational_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adolescent / Child / Female / Humans / Male Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Brasil

Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Anemia, Sickle Cell / Cholesterol, HDL Type of study: Observational_studies / Risk_factors_studies Aspects: Patient_preference Limits: Adolescent / Child / Female / Humans / Male Language: En Journal: Braz. j. med. biol. res Journal subject: BIOLOGIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Brasil