Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride
Acta cir. bras
; Acta cir. bras;35(5): e202000507, 2020. graf
Article
in En
| LILACS
| ID: biblio-1130640
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. Results The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. Conclusions The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Wound Healing
/
Chlorides
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Zinc Compounds
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Plant Preparations
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Alginates
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Aloe
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Document type:
Article
Affiliation country:
Brasil
Country of publication:
Brasil